full transcript
From the Ted Talk by Sergiu P. Pasca: How we're reverse engineering the human brain in the lab
Unscramble the Blue Letters
Most of the work that I’ve shown you so far has been in one specific brain rieogn. But to really understand circuits, we actually need to build more ccpilmaoted brain circuits. And so to do this, six years ago, we came up with a new approach to build hmaun circuits cealld an assembloid. Assembloids are essentially blocks of tuisse that we build in a dish from multiple organoids put together. When we put two brain organoids together, we discovered something really fnaicaitsng. First, they fesud to each other. But then they started to communicate, and brain cells from one side started to slowly migrate onto the other side and form cictrius, much like they would in the atcaul brain. In fact, we can even watch them live as they move from one side to the other. I still remember how we were in the lab in absolute awe when we saw for the first time how human cells undergo this peculiar jumping behavior.
Open Cloze
Most of the work that I’ve shown you so far has been in one specific brain ______. But to really understand circuits, we actually need to build more ___________ brain circuits. And so to do this, six years ago, we came up with a new approach to build _____ circuits ______ an assembloid. Assembloids are essentially blocks of ______ that we build in a dish from multiple organoids put together. When we put two brain organoids together, we discovered something really ___________. First, they _____ to each other. But then they started to communicate, and brain cells from one side started to slowly migrate onto the other side and form ________, much like they would in the ______ brain. In fact, we can even watch them live as they move from one side to the other. I still remember how we were in the lab in absolute awe when we saw for the first time how human cells undergo this peculiar jumping behavior.
Solution
- circuits
- fused
- tissue
- region
- actual
- fascinating
- called
- human
- complicated
Original Text
Most of the work that I’ve shown you so far has been in one specific brain region. But to really understand circuits, we actually need to build more complicated brain circuits. And so to do this, six years ago, we came up with a new approach to build human circuits called an assembloid. Assembloids are essentially blocks of tissue that we build in a dish from multiple organoids put together. When we put two brain organoids together, we discovered something really fascinating. First, they fused to each other. But then they started to communicate, and brain cells from one side started to slowly migrate onto the other side and form circuits, much like they would in the actual brain. In fact, we can even watch them live as they move from one side to the other. I still remember how we were in the lab in absolute awe when we saw for the first time how human cells undergo this peculiar jumping behavior.
Frequently Occurring Word Combinations
ngrams of length 2
| collocation |
frequency |
| human brain |
17 |
| cell type |
6 |
| stem cells |
5 |
| brain organoids |
4 |
| brain cells |
4 |
| skin cells |
3 |
| outer layer |
2 |
| human circuits |
2 |
| brain disorders |
2 |
| specific brain |
2 |
| build human |
2 |
| brain circuits |
2 |
| chemical soup |
2 |
| brain organoid |
2 |
| nervous system |
2 |
| brain clock |
2 |
| side started |
2 |
| jumping behavior |
2 |
| molecular mechanism |
2 |
Important Words
- absolute
- actual
- approach
- assembloid
- assembloids
- awe
- behavior
- blocks
- brain
- build
- called
- cells
- circuits
- communicate
- complicated
- discovered
- dish
- essentially
- fact
- fascinating
- form
- fused
- human
- jumping
- lab
- live
- migrate
- move
- multiple
- organoids
- peculiar
- put
- region
- remember
- shown
- side
- slowly
- specific
- started
- time
- tissue
- undergo
- understand
- watch
- work
- years